3-D Printed Ovaries Yield New Life


Date: 16.05.2017
source: discovermagazine.com

It’s another success for members of the same Northwestern University team that in March reproduced an entire menstrual cycle using organs-on-a-chip. This time, they’ve created ovaries from a type of gelatin hydrogel and infused them with immature egg cells before implanting them in female mice. The ovaries behaved like the natural ones, picking out an egg cell to mature and pass along, allowing the mice to bear healthy offspring. The procedure marks another step toward printing replacements for missing or damaged organs.

From Skeleton to Organ

To create their ovaries, the researchers, led by Theresa Woodruff, the director of the Women’s Health Research Institute at Northwestern’s Feinberg School of Medicine, first learned to print the gelatin at exactly the right consistency. It had to be strong enough to handle surgical implantation while porous enough to hold on to egg cells and allow veins to grow. Through a series of trial and error experiments, the researchers discovered the best way to print the scaffolding from gelatin fibers that contained a series of tiny pockets to hold ovarian follicles.

read the whole article @ http://blogs.discovermagazine.com/d-brief/2017/05/16/3d-printed-ovaries-mice/#.WRuCOu0y_tR

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